abstract：BACKGROUND:Nitric oxide (NO) is a gaseous molecule that modulates several physiological processes, including signal transmission in the central nervous system. There is evidence supporting NO as a major neurotransmitter involved in motor and emotion/behavior control. We investigated the distribution and morphology of n...

journal_title：Brain research bulletin

authors： Santos-Lobato BL,Del-Bel E,Pittella JE,Tumas V

更新日期：2016-06-01 00:00:00

abstract：:The non-adenosine nucleoside guanosine (Guo) was demonstrated to decrease quinolinic acid(QA)-induced seizures, spontaneously emerged absence epileptic seizures and lipopolysaccharide(LPS)-evoked induction of absence epileptic seizures suggesting its antiepileptic potential. It was also described previously that intra...

journal_title：Brain research bulletin

authors： Lakatos RK,Dobolyi Á,Todorov MI,Kékesi KA,Juhász G,Aleksza M,Kovács Z

更新日期：2016-06-01 00:00:00

abstract：:Here we asked if insulin activation of the nucleus accumbens in vitro is reflected by an increase in (3)H-deoxyglucose ([(3)H]DG) uptake, thus subserving a new model to study molecular mechanisms of central insulin actions. Additionally, we investigated the dependence of this insulin effect on endocannabinoids and cor...

journal_title：Brain research bulletin

authors： Pinheiro BS,Lemos C,Neutzling Kaufmann F,Marques JM,da Silva-Santos CS,Carvalho E,Mackie K,Rodrigues RJ,Cunha RA,Köfalvi A

更新日期：2016-06-01 00:00:00

abstract：:Several studies have demonstrated alterations in the dopamine (DA) system after traumatic brain injury (TBI). Additionally, the existence of significant sex-related differences in the dopaminergic system has long been recognized. Accordingly, the purpose of the present study was to investigate whether TBI would differ...

journal_title：Brain research bulletin

authors： Xu X,Cao S,Chao H,Liu Y,Ji J

更新日期：2016-06-01 00:00:00

abstract：:Chronic exposure to drugs and alcohol leads to damage to dopaminergic neurons and their projections in the 'reward pathway' that originate in the ventral tegmental area (VTA) and terminate in the nucleus accumbens (NAc). This damage is thought to contribute to the signature symptom of addiction: chronic relapse. In th...

journal_title：Brain research bulletin

authors： Venkiteswaran K,Alexander DN,Puhl MD,Rao A,Piquet AL,Nyland JE,Subramanian MP,Iyer P,Boisvert MM,Handly E,Subramanian T,Grigson PS

更新日期：2016-05-01 00:00:00

abstract：:Human autopsy brain tissue is widely used to study neurodegenerative diseases such as Alzheimer's, Parkinson's and other diseases. However, when it comes to an evaluation of data obtained from such tissue, it is essential to consider potential postmortem effects on protein composition, posttranslational modification a...

journal_title：Brain research bulletin

authors： ElHajj Z,Cachot A,Müller T,Riederer IM,Riederer BM

更新日期：2016-03-01 00:00:00

abstract：:Various reports have suggested that penehyclidine hydrochloride (PHC), a new cholinergic antagonist, exhibits a variety of biological actions such as anti-tumor and cardioprotective effects. This study aimed to investigate the effects of PHC on cerebral ischemia/reperfusion (I/R) injury and evaluate whether the c-Jun ...

journal_title：Brain research bulletin

authors： Shu Y,Yang Y,Zhang P

更新日期：2016-03-01 00:00:00

abstract：:It has been wildly accepted that willed movement(WM) training promotes neurological rehabilitation in patients with stroke. However, it was not clear whether the effect of WM is better than other forms of exercise. The purpose of this study is to assess different effects of WM and other forms of exercise on rats with ...

journal_title：Brain research bulletin

authors： Nie J,Yang X,Tang Q,Shen Q,Li S

更新日期：2016-01-01 00:00:00

abstract：:Increases in expression of α4βδ GABAA receptors (GABARs), triggered by fluctuations in the neurosteroid THP (3α-OH-5α[β]-pregnan-20-one), are associated with changes in mood and cognition. We tested whether α4βδ trafficking and surface expression would be altered by in vitro exposure to flumazenil, a benzodiazepine li...

journal_title：Brain research bulletin

authors： Kuver A,Smith SS

更新日期：2016-01-01 00:00:00

abstract：:Bacillus Calmette-Guérin (BCG) is administered to neonates worldwide, but it is still unknown whether this neonatal vaccination affects brain development during early postnatal life, despite the close association of the immune system with the brain. Newborn C57BL/6 mice were injected subcutaneously with BCG or phospha...

journal_title：Brain research bulletin

authors： Yang J,Qi F,Gu H,Zou J,Yang Y,Yuan Q,Yao Z

更新日期：2016-01-01 00:00:00

abstract：:Chronic brain implants are accompanied by a tissue response that causes the loss of neurons in the vicinity of the implant and the formation of a glial scar that is also referred to as foreign body response. Despite immense progress in the field of brain-computer interface (BCI) research the biocompatibility of chroni...

journal_title：Brain research bulletin

authors： Hayn L,Koch M

更新日期：2015-08-01 00:00:00

abstract：:Alzheimer's disease is a neurodegenerative disease associated with progressive memory and cognitive decline. Previous studies have identified the benefits of cognitive enrichment on reducing disease pathology. Additionally, epidemiological and clinical data suggest that repeated exercise, and cognitive and social enri...

journal_title：Brain research bulletin

authors： Martinez-Coria H,Yeung ST,Ager RR,Rodriguez-Ortiz CJ,Baglietto-Vargas D,LaFerla FM

更新日期：2015-08-01 00:00:00

abstract：:Migraine and dizziness are relatively common disorders. Patients with dizziness have a higher incidence of migraines than the general population. The discomfort experienced by these patients is often poorly controlled by medication. However, the pathophysiology of vestibular migraine (VM) remains unclear. We hypothesi...

journal_title：Brain research bulletin

authors： Lee YY,Yang YP,Huang PI,Li WC,Huang MC,Kao CL,Chen YJ,Chen MT

更新日期：2015-07-01 00:00:00

abstract：:The effects of Fe(2+) and Fe(3+) on glycine-activated chloride current (IGly) were studied in rat isolated pyramidal hippocampal neurons using patch-clamp technique in whole-cell configuration. 25, 100 or 500 μM glycine was applied for 600 ms with 40s intervals. Fe(2+) and Fe(3+) were co-applied with glycine in the ra...

journal_title：Brain research bulletin

authors： Solntseva EI,Bukanova JV,Kondratenko RV,Skrebitsky VG

更新日期：2015-06-01 00:00:00

abstract：:Patients with post-traumatic stress disorder (PTSD) tend to misinterpret innocuous stimuli as potential threats, possibly due to a conditioning provoked by traumatic episodes. Previous neuroimaging evidence has shown an abnormal activation of the amygdala and prefrontal cortex in PTSD patients during fear conditioning...

journal_title：Brain research bulletin

authors： Brunetti M,Sepede G,Ferretti A,Mingoia G,Romani GL,Babiloni C

更新日期：2015-05-01 00:00:00

abstract：:Diabetic encephalopathy has recently been recognized late complication of diabetes resulting in progressive cognitive deficits. Emerging evidence has indicated that endoplasmic reticulum (ER) stress-mediated apoptosis is involved in the pathogenesis of diabetic eye and kidney as well as non-diabetic neurodegeneration....

journal_title：Brain research bulletin

authors： Zhao Y,Yan Y,Zhao Z,Li S,Yin J

更新日期：2015-02-01 00:00:00

abstract：:Degeneration of substantia nigra dopaminergic neurons is a key pathological change of Parkinson's disease (PD), and its motor consequences have been widely recognized. Recently, mood disorders associated with PD have begun to attract a great deal of interest, however, their pathogenesis remains unclear. PD is associat...

journal_title：Brain research bulletin

authors： Luo XF,Zhang BL,Li JC,Yang YY,Sun YF,Zhao H

更新日期：2015-01-01 00:00:00

abstract：:Glutamate afferents reaching the ventral tegmental area (VTA) affect dopamine (DA) cells in this structure probably mainly via NMDA receptors. VTA appears to be one of the structures involved in regulation of hippocampal theta rhythm, and this work aimed at assessing the role of glutamatergic activation of the VTA in ...

journal_title：Brain research bulletin

authors： Matulewicz P,Orzeł-Gryglewska J,Kuśmierczak M,Jurkowlaniec E

更新日期：2014-08-01 00:00:00

abstract：:We showed previously that the number and time of spike-wave discharges (SWDs) were increased after intraperitoneal (i.p.) injection of lipopolysaccharide (LPS), an effect, which was completely abolished by cyclooxygenase-2 (COX-2) inhibitor indomethacin (IND) pretreatment in Wistar Albino Glaxo/Rijswijk (WAG/Rij) rats...

journal_title：Brain research bulletin

authors： Kovács Z,Dobolyi A,Juhász G,Kékesi KA

更新日期：2014-05-01 00:00:00

abstract：:Nitric oxide (NO) is the main activator of the soluble guanylate cyclase (sGC)-guanosine 3'5' cyclic monophosphate (cGMP) pathway. The level of cGMP is regulated by phosphodiesterases (PDEs), which break down cGMP. It has been reported that levels of NO in the central nervous system (CNS) can greatly increase during d...

journal_title：Brain research bulletin

authors： Rapôso C,Luna RL,Nunes AK,Thomé R,Peixoto CA

更新日期：2014-05-01 00:00:00

abstract：:Epigenetic processes are involved in regulation of cell functions and survival, but their role in responses of neurons and glial cells to oxidative injury is insufficiently explored. Here, we studied the role of DNA methylation and histone deacetylation in reactions of neurons and surrounding glial cells to photodynam...

journal_title：Brain research bulletin

authors： Sharifulina SA,Komandirov MA,Uzdensky AB

更新日期：2014-03-01 00:00:00

abstract：:Intracerebral hemorrhage (ICH) is a devastating form of stroke leading to a high rate of death and disability worldwide. Although it has been hypothesized that much of the IHC insult occurs in the subacute period mediated via a series of complex pathophysiological cascades, the molecular mechanisms involved in ICH hav...

journal_title：Brain research bulletin

authors： Ren C,Guingab-Cagmat J,Kobeissy F,Zoltewicz S,Mondello S,Gao M,Hafeez A,Li N,Geng X,Larner SF,Anagli J,Hayes RL,Ji X,Ding Y

更新日期：2014-03-01 00:00:00

abstract：:Ocular enucleation induces profound morphological alterations in central visual areas. However, little is known about the response of glial cells and possible inflammatory processes in visual brain areas resulting from eye enucleation. In this study, immunoblotting and immunostaining assays revealed increased expressi...

journal_title：Brain research bulletin

authors： Hernandes MS,Britto LR

更新日期：2014-02-01 00:00:00

abstract：:A recent in vitro electrophysiological analysis combined with anatomical approach suggests that a potential disinhibitory mechanism involving somatostatin (SST), which is released by interneurons in the superficial dorsal horn, contributes to nociceptive transmission (Yasaka et al., 2010); however, whether this mechan...

journal_title：Brain research bulletin

authors： Takahashi M,Takeda M,Matsumoto S

更新日期：2014-01-01 00:00:00

abstract：:Tolperisone is a voltage gated sodium channel blocker, centrally acting muscle relaxant drug, with a very advantageous side effect profile. Like other sodium channel blockers, it has weak affinity to the resting state and high affinity to the open/inactivated state of the channel. In this paper, its effect on BOLD res...

journal_title：Brain research bulletin

authors： Kocsis P,Gajári D,Deli L,Gőcze KZ,Pozsgay Z,Tihanyi K

更新日期：2013-10-01 00:00:00

abstract：:Prey-catching behavior (PCB) of the frog consists of a sequence of coordinated activity of muscles which is modified by various sensory signals. The aim of the present study was, for the first time, to examine the involvement of the trigeminal afferents in the swallowing phase of PCB. Experiments were performed on Ran...

journal_title：Brain research bulletin

authors： Kecskes S,Matesz C,Birinyi A

更新日期：2013-10-01 00:00:00

abstract：:Concomitant behavioral and dorsal raphe (DR) neuronal activity were recorded following acute and chronic dose response of methylphenidate (MPD) in freely moving rats previously implanted with permanent semi-microelectrodes using telemetric (wireless) technology. On experimental day (ED) 1, the neuronal and locomotor a...

journal_title：Brain research bulletin

authors： Tang B,Dafny N

更新日期：2013-09-01 00:00:00

abstract：:A high proportion of patients who have suffered a stroke also suffer from aphasia. Approximately half of those affected will remain in this state despite intensive language therapy. Non-invasive brain stimulation allows us to directly and focally stimulate areas of the brain. Repetitive transcranial magnetic stimulati...

journal_title：Brain research bulletin

authors： Málly J

更新日期：2013-09-01 00:00:00

abstract：:Recent findings in epigenetics shed new light on the regulation of gene expression in the central nervous system (CNS) during stress. The most frequently studied epigenetic mechanisms are DNA methylation, histone modifications and microRNA activity. These mechanisms stably determine cell phenotype but can also be resp...

journal_title：Brain research bulletin

authors： Stankiewicz AM,Swiergiel AH,Lisowski P

更新日期：2013-09-01 00:00:00

abstract：:High-fat (HF) diet and obesity are risk factors for a number of mental health problems including depression, cognitive dysfunction, dementia, and neurodegenerative diseases. Histamine H1 receptors (H1Rs) are involved in many of these conditions. This study examined H1R receptor binding density in the brain of male rat...

journal_title：Brain research bulletin

authors： Wu Z,Yu Y,Wu Y,Patch C,Szabo A,Huang XF

更新日期：2013-08-01 00:00:00

abstract：:In brainstem slices of male rats, we examined in single neurons of the medial vestibular nucleus (MVN) the effect of exogenous administration of estrogenic (17β-estradiol, E2) and androgenic (5α-dihydrotestosterone, DHT) steroids on the synaptic response to vestibular afferent stimulation. By whole cell patch clamp re...

journal_title：Brain research bulletin

authors： Grassi S,Scarduzio M,Panichi R,Dall'Aglio C,Boiti C,Pettorossi VE

更新日期：2013-08-01 00:00:00

abstract：:As nicotinic acetylcholine receptor (nAChR) agonists directly address cholinergic neurotransmission with potential impact on glutamatergic function, they are considered as potential new symptomatic treatment options for Alzheimer's disease compared to the indirectly operating acetylcholinesterase inhibitors such as th...

journal_title：Brain research bulletin

authors： Kroker KS,Moreth J,Kussmaul L,Rast G,Rosenbrock H

更新日期：2013-07-01 00:00:00

abstract：:Astrocytes become activated and proliferate in response to autoimmune diseases involving the CNS. In many cases, elevated numbers of astrocytes may compound inflammatory responses and exacerbate neuronal degeneration. The regulation of astrocytes in disease states has been shown as an important corollary to disease pr...

journal_title：Brain research bulletin

authors： Campbell AM,Zagon IS,McLaughlin PJ

更新日期：2013-01-01 00:00:00

abstract：:Serotonin transporter (SERT) and brain-derived neurotrophic factor (BDNF) are key modulators of molecular signaling, cognition and behavior. Although SERT and BDNF mutant mouse phenotypes have been extensively characterized, little is known about their self-grooming behavior. Grooming represents an important behaviora...

journal_title：Brain research bulletin

authors： Kyzar EJ,Pham M,Roth A,Cachat J,Green J,Gaikwad S,Kalueff AV

更新日期：2012-12-01 00:00:00

abstract：:Pregnancy involves changes in brain function that implicate a re-organization in neuronal cytoskeleton. We analyzed the content of the microtubule associated protein Tau (65kDa isoform) and its phosphorylated form (PhosphoTau) in several rat brain regions throughout pregnancy and on day 2 of lactation by Western blot....

journal_title：Brain research bulletin

authors： González-Arenas A,Piña-Medina AG,González-Flores O,Gómora-Arrati P,Carrillo-Martínez GE,Balandrán-Ruíz MA,Camacho-Arroyo I

更新日期：2012-11-01 00:00:00

abstract：:The present study investigates the protective effects of electroacupuncture (EA) application on cardiac function, while simultaneously exploring the underlying neurobiological mechanisms, in rats that have experienced thoracic surgery-induced stress. Mean arterial and left intraventricular pressures were monitored as ...

journal_title：Brain research bulletin

authors： Zhang HH,Chen J,Xia CM,Jiang MY,Wang J,Cao YX,Shen LL,Wang MY,Zhu DN

更新日期：2012-10-01 00:00:00

abstract：:In female rats, stimulation of the uterine cervix during mating induces two daily surges of prolactin. Inhibition of hypothalamic dopamine release and stimulation of oxytocin neurons in the paraventricular nucleus (PVN) are required for prolactin secretion. We aim to better understand how stimulation of the uterine ce...

journal_title：Brain research bulletin

authors： Poletini MO,McKee DT,Szawka RE,Bertram R,Helena CV,Freeman ME

更新日期：2012-09-01 00:00:00

abstract：:Flinders Sensitive Line (FSL) rat is as an animal model of depression with altered parameters of the serotonergic (5-HT) system function (5-HT synthesis rates, tissue concentrations, release, receptor density and affinity), as well as an altered sensitivity of these parameters to different 5-HT based antidepressants. ...

journal_title：Brain research bulletin

authors： Skelin I,Kovačević T,Sato H,Diksic M

更新日期：2012-08-01 00:00:00

abstract：:Mechanisms underlying shock-induced conditioned fear - a paradigm frequently used to model posttraumatic stress disorder, PTSD - are usually studied shortly after shocks. Some of the brain regions relevant to conditioned fear were activated in all the c-Fos studies published so far, but the overlap between the activat...

journal_title：Brain research bulletin

authors： Tulogdi A,Sörös P,Tóth M,Nagy R,Biró L,Aliczki M,Klausz B,Mikics E,Haller J

更新日期：2012-07-01 00:00:00

abstract：:The issue of possible neurobiological effects of the electromagnetic field (EMF) exposure is highly controversial. To determine whether electromagnetic field exposure could act as an environmental stimulus capable of producing stress responses, we employed the hippocampus, a sensitive target of electromagnetic radiati...

journal_title：Brain research bulletin

authors： Yang XS,He GL,Hao YT,Xiao Y,Chen CH,Zhang GB,Yu ZP

更新日期：2012-07-01 00:00:00